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type="integer">1</cn></apply><apply><eq /><ci>sa170</ci><cn type="integer">0</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re42"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_csa34"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa21" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_csa34_in_0" /><qual:input qual:qualitativeSpecies="sa170" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_csa34_in_1" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="csa34" qual:transitionEffect="assignmentLevel" qual:id="tr_csa34_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>csa21</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa170</ci><cn type="integer">0</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re62"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa26"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa34" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa26_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa26" qual:transitionEffect="assignmentLevel" qual:id="tr_sa26_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa34</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re12"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa27"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa26" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa27_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa27" qual:transitionEffect="assignmentLevel" qual:id="tr_sa27_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa26</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re9"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa30"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa39" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa30_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa30" qual:transitionEffect="assignmentLevel" qual:id="tr_sa30_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa39</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re14"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa31"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa30" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa31_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa31" qual:transitionEffect="assignmentLevel" qual:id="tr_sa31_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa30</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re8"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa34"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa35" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa34_in_0" /><qual:input qual:qualitativeSpecies="sa115" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa34_in_1" /><qual:input qual:qualitativeSpecies="csa34" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa34_in_2" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa34" qual:transitionEffect="assignmentLevel" qual:id="tr_sa34_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>csa35</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa115</ci><cn type="integer">1</cn></apply><apply><eq /><ci>csa34</ci><cn type="integer">1</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re10"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa39"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa35" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa39_in_0" /><qual:input qual:qualitativeSpecies="sa115" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa39_in_1" /><qual:input qual:qualitativeSpecies="csa34" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa39_in_2" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa39" qual:transitionEffect="assignmentLevel" qual:id="tr_sa39_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>csa35</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa115</ci><cn type="integer">1</cn></apply><apply><eq /><ci>csa34</ci><cn type="integer">1</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re13"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa45"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa6" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa45_in_0" /><qual:input qual:qualitativeSpecies="sa122" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa45_in_1" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa45" qual:transitionEffect="assignmentLevel" qual:id="tr_sa45_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>csa6</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa122</ci><cn type="integer">1</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>WP4868 </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re16"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:wikipathways:WP4868" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa48"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa6" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa48_in_0" /><qual:input qual:qualitativeSpecies="sa122" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa48_in_1" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa48" qual:transitionEffect="assignmentLevel" qual:id="tr_sa48_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>csa6</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa122</ci><cn type="integer">1</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>WP4868 </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re17"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:wikipathways:WP4868" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa50"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa159" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa50_in_0" /><qual:input qual:qualitativeSpecies="sa129" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa50_in_1" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa50" qual:transitionEffect="assignmentLevel" qual:id="tr_sa50_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>sa159</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa129</ci><cn type="integer">0</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re67"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:694009" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa51"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa48" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa51_in_0" /><qual:input qual:qualitativeSpecies="sa129" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa51_in_1" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa51" qual:transitionEffect="assignmentLevel" qual:id="tr_sa51_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><or /><apply><eq /><ci>sa48</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa129</ci><cn type="integer">0</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>WP4868 </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re19"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> <rdf:Description rdf:about="#re68"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:694009" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa55"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa185" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa55_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa55" qual:transitionEffect="assignmentLevel" qual:id="tr_sa55_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa185</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re75"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa59"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa20" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa59_in_0" /><qual:input qual:qualitativeSpecies="sa123" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa59_in_1" /><qual:input qual:qualitativeSpecies="sa204" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa59_in_2" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa59" qual:transitionEffect="assignmentLevel" qual:id="tr_sa59_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>csa20</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa123</ci><cn type="integer">0</cn></apply><apply><eq /><ci>sa204</ci><cn type="integer">0</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re23"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:694009" /> </rdf:Bag> </bqbiol:isEncodedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:25135833" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa61"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa116" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa61_in_0" /><qual:input qual:qualitativeSpecies="sa172" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa61_in_1" /><qual:input qual:qualitativeSpecies="sa151" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa61_in_2" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa61" qual:transitionEffect="assignmentLevel" qual:id="tr_sa61_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><or /><apply><eq /><ci>sa116</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa172</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa151</ci><cn type="integer">1</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>SIGNOR-SCISOVG: SIGNOR-260155: SIGNOR-260153: SIGNOR-260145: SIGNOR-260593 </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re24"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:24622840" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:25636800" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:26631542" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa74"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa6" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa74_in_0" /><qual:input qual:qualitativeSpecies="sa122" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa74_in_1" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa74" qual:transitionEffect="assignmentLevel" qual:id="tr_sa74_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>csa6</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa122</ci><cn type="integer">1</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>WP4868 </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re31"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:wikipathways:WP4868" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa76"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa158" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa76_in_0" /><qual:input qual:qualitativeSpecies="sa129" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa76_in_1" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa76" qual:transitionEffect="assignmentLevel" qual:id="tr_sa76_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>sa158</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa129</ci><cn type="integer">0</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re66"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:694009" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa78"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa6" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa78_in_0" /><qual:input qual:qualitativeSpecies="sa122" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa78_in_1" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa78" qual:transitionEffect="assignmentLevel" qual:id="tr_sa78_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>csa6</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa122</ci><cn type="integer">1</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>WP4868 </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re33"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:wikipathways:WP4868" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa80"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa157" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa80_in_0" /><qual:input qual:qualitativeSpecies="sa129" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa80_in_1" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa80" qual:transitionEffect="assignmentLevel" qual:id="tr_sa80_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>sa157</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa129</ci><cn type="integer">0</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re65"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:694009" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa81"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa122" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa81_in_0" /><qual:input qual:qualitativeSpecies="csa34" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa81_in_1" /><qual:input qual:qualitativeSpecies="sa212" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa81_in_2" /><qual:input qual:qualitativeSpecies="csa32" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa81_in_3" /><qual:input qual:qualitativeSpecies="sa123" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa81_in_4" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa81" qual:transitionEffect="assignmentLevel" qual:id="tr_sa81_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><or /><apply><eq /><ci>sa122</ci><cn type="integer">1</cn></apply><apply><eq /><ci>csa34</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa212</ci><cn type="integer">1</cn></apply><apply><eq /><ci>csa32</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa123</ci><cn type="integer">0</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>SIGNOR-SCISOVG </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re91"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:12692549" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:19380580" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> <rdf:Description rdf:about="#re92"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:12692549" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> <rdf:Description rdf:about="#re93"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:19380580" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> <rdf:Description rdf:about="#re97"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:wikipathways:WP4868" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> <rdf:Description rdf:about="#re98"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:694009" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa83"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa20" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa83_in_0" /><qual:input qual:qualitativeSpecies="sa123" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa83_in_1" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa83" qual:transitionEffect="assignmentLevel" qual:id="tr_sa83_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>csa20</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa123</ci><cn type="integer">0</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re39"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:694009" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa86"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa59" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa86_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa86" qual:transitionEffect="assignmentLevel" qual:id="tr_sa86_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa59</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re40"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa109"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa18" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa109_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa109" qual:transitionEffect="assignmentLevel" qual:id="tr_sa109_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>csa18</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re101"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa114"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa18" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa114_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa114" qual:transitionEffect="assignmentLevel" qual:id="tr_sa114_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>csa18</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re101"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa115"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa114" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa115_in_0" /><qual:input qual:qualitativeSpecies="sa170" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa115_in_1" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa115" qual:transitionEffect="assignmentLevel" qual:id="tr_sa115_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>sa114</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa170</ci><cn type="integer">0</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>WP4868: The inhibition of SARS-CoV-2 PLpro by GRL0617 is proposed based on Ratia, et al. 2008 and 100% sequence identity between SARS-CoV and SARS-CoV-2 across all 13 residues of PLpro involved in binding GRL0617 (82.9% identity across 316 amino acids) as determined by the alignment of RefSeq YP_009725299.1 and PDB 3E9S (https://alexanderpico.github.io/SARS-CoV-2_Alignments/#Nsp3_PLpro_domain). The antimicrobial agent, azithromycin, is in clincal trials as COVID-19 therapy in combination with hydroxychloroquine (Gautret 2020) has been shown to modulate inflammation by inhibiting the activation of many of these same transcription factors. </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re50"> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:wikipathways:WP4868" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa116"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa123" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa116_in_0" /><qual:input qual:qualitativeSpecies="sa61" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa116_in_1" /><qual:input qual:qualitativeSpecies="sa151" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa116_in_2" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa116" qual:transitionEffect="assignmentLevel" qual:id="tr_sa116_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><or /><apply><eq /><ci>sa61</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa151</ci><cn type="integer">1</cn></apply></apply><apply><eq /><ci>sa123</ci><cn type="integer">0</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>SIGNOR-SCISOVG: SIGNOR-178053: SIGNOR-260144: SIGNOR-260592 </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re52"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:18353649" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:25636800" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:694009" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa121"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa19" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa121_in_0" /><qual:input qual:qualitativeSpecies="sa123" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa121_in_1" /><qual:input qual:qualitativeSpecies="sa140" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa121_in_2" /><qual:input qual:qualitativeSpecies="csa26" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa121_in_3" /><qual:input qual:qualitativeSpecies="csa27" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa121_in_4" /><qual:input qual:qualitativeSpecies="sa61" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa121_in_5" /><qual:input qual:qualitativeSpecies="sa127" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa121_in_6" /><qual:input qual:qualitativeSpecies="sa184" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa121_in_7" /><qual:input qual:qualitativeSpecies="sa151" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa121_in_8" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa121" qual:transitionEffect="assignmentLevel" qual:id="tr_sa121_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><or /><apply><eq /><ci>csa19</ci><cn type="integer">1</cn></apply><apply><eq /><ci>csa26</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa61</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa151</ci><cn type="integer">1</cn></apply></apply><apply><eq /><ci>sa123</ci><cn type="integer">0</cn></apply><apply><eq /><ci>sa140</ci><cn type="integer">0</cn></apply><apply><eq /><ci>csa27</ci><cn type="integer">0</cn></apply><apply><eq /><ci>sa127</ci><cn type="integer">0</cn></apply><apply><eq /><ci>sa184</ci><cn type="integer">0</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>SIGNOR-SCISOVG: SIGNOR-260239: SIGNOR-260240: SIGNOR-260249: SIGNOR-260154: SIGNOR-260337: SIGNOR-260338: SIGNOR-260339: SIGNOR-120355: SIGNOR-178395: SIGNOR-178399: SIGNOR-178403: SIGNOR-178411: SIGNOR-178420: SIGNOR-178391: SIGNOR-260143 </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re54"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:14679297" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:17108024" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:24622840" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:25481026" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:25636800" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:29294448" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:17761676" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:18440553" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:694009" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa122"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa121" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa122_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa122" qual:transitionEffect="assignmentLevel" qual:id="tr_sa122_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa121</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>WP4868 </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re55"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:19380580" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa123"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa168" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa123_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa123" qual:transitionEffect="assignmentLevel" qual:id="tr_sa123_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa168</ci><cn type="integer">0</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>WP4868: The inhibition of SARS-CoV-2 PLpro by GRL0617 is proposed based on Ratia, et al. 2008 and 100% sequence identity between SARS-CoV and SARS-CoV-2 across all 13 residues of PLpro involved in binding GRL0617 (82.9% identity across 316 amino acids) as determined by the alignment of RefSeq YP_009725299.1 and PDB 3E9S (https://alexanderpico.github.io/SARS-CoV-2_Alignments/#Nsp3_PLpro_domain). The antimicrobial agent, azithromycin, is in clincal trials as COVID-19 therapy in combination with hydroxychloroquine (Gautret 2020) has been shown to modulate inflammation by inhibiting the activation of many of these same transcription factors. </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re71"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa144"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa20" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa144_in_0" /><qual:input qual:qualitativeSpecies="sa151" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa144_in_1" /><qual:input qual:qualitativeSpecies="sa141" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa144_in_2" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa144" qual:transitionEffect="assignmentLevel" qual:id="tr_sa144_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><or /><apply><eq /><ci>csa20</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa151</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa141</ci><cn type="integer">1</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re58"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:20404851" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa151"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa23" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa151_in_0" /><qual:input qual:qualitativeSpecies="sa139" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa151_in_1" /><qual:input qual:qualitativeSpecies="sa204" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa151_in_2" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa151" qual:transitionEffect="assignmentLevel" qual:id="tr_sa151_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>csa23</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa139</ci><cn type="integer">0</cn></apply><apply><eq /><ci>sa204</ci><cn type="integer">0</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>SIGNOR-SCISOVG: SIGNOR-260139: SIGNOR-260140: SIGNOR-260241: </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re64"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:19052324" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:25135833" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:694009" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa154"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa227" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa154_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa154" qual:transitionEffect="assignmentLevel" qual:id="tr_sa154_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa227</ci><cn type="integer">0</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>SIGNOR-SCISOVG </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re76"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:28158275" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:694009" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa155"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa140" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa155_in_0" /><qual:input qual:qualitativeSpecies="sa201" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa155_in_1" /><qual:input qual:qualitativeSpecies="sa202" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa155_in_2" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa155" qual:transitionEffect="assignmentLevel" qual:id="tr_sa155_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><or /><apply><eq /><ci>sa201</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa202</ci><cn type="integer">1</cn></apply></apply><apply><eq /><ci>sa140</ci><cn type="integer">0</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re80"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:25581309" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:28148787" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:694009" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa157"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa78" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa157_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa157" qual:transitionEffect="assignmentLevel" qual:id="tr_sa157_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa78</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>WP4868 </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re34"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa158"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa74" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa158_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa158" qual:transitionEffect="assignmentLevel" qual:id="tr_sa158_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa74</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>WP4868 </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re32"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa159"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa45" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa159_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa159" qual:transitionEffect="assignmentLevel" qual:id="tr_sa159_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa45</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>WP4868 </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re18"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa172"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa151" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa172_in_0" /><qual:input qual:qualitativeSpecies="sa184" qual:transitionEffect="none" qual:sign="negative" qual:id="tr_sa172_in_1" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa172" qual:transitionEffect="assignmentLevel" qual:id="tr_sa172_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><and /><apply><eq /><ci>sa151</ci><cn type="integer">1</cn></apply><apply><eq /><ci>sa184</ci><cn type="integer">0</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>SIGNOR-SCISOVG: SIGNOR-260247: SIGNOR-260152 </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re72"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:22312431" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:24622840" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:694009" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa186"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa162" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa186_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa186" qual:transitionEffect="assignmentLevel" qual:id="tr_sa186_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa162</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>SIGNOR-SCISOVG: SIGNOR-260587 </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re69"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:31226023" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:694009" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa196"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa34" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa196_in_0" /><qual:input qual:qualitativeSpecies="csa30" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa196_in_1" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa196" qual:transitionEffect="assignmentLevel" qual:id="tr_sa196_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><or /><apply><eq /><ci>csa34</ci><cn type="integer">1</cn></apply><apply><eq /><ci>csa30</ci><cn type="integer">1</cn></apply></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>SIGNOR-SCIR </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re99"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:20457564" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> <rdf:Description rdf:about="#re100"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:32133002" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa204"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa139" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa204_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa204" qual:transitionEffect="assignmentLevel" qual:id="tr_sa204_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa139</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><notes><html xmlns="http://www.w3.org/1999/xhtml"><head><title /></head><body><p>Also, acting on mitochondria ORF-9b targets the mitochondrial-associated adaptor molecule MAVS signalosome by usurping poly(C)-binding protein 2 (PCBP2) and the HECT domain E3 ligase AIP4 to trigger the degradation of MAVS, TRAF3, and TRAF6. This severely limits host cell interferon responses. Reducing either PCBP2 or AIP4 expression substantially reversed the ORF-9b mediated reduction of MAVS and the suppression of anti-viral transcriptional responses. </p> </body></html></notes><annotation><rdf:RDF><rdf:Description rdf:about="#re81"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:25135833" /> </rdf:Bag> </bqbiol:isDescribedBy> <bqbiol:isEncodedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:taxonomy:694009" /> </rdf:Bag> </bqbiol:isEncodedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa211"><qual:listOfInputs><qual:input qual:qualitativeSpecies="csa19" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa211_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa211" qual:transitionEffect="assignmentLevel" qual:id="tr_sa211_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>csa19</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re84"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:19380580" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition><qual:transition qual:id="tr_sa212"><qual:listOfInputs><qual:input qual:qualitativeSpecies="sa211" qual:transitionEffect="none" qual:sign="positive" qual:id="tr_sa212_in_0" /></qual:listOfInputs><qual:listOfOutputs><qual:output qual:qualitativeSpecies="sa212" qual:transitionEffect="assignmentLevel" qual:id="tr_sa212_out" /></qual:listOfOutputs><qual:listOfFunctionTerms><qual:defaultTerm qual:resultLevel="0" /><qual:functionTerm qual:resultLevel="1"><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq /><ci>sa211</ci><cn type="integer">1</cn></apply></math></qual:functionTerm></qual:listOfFunctionTerms><annotation><rdf:RDF><rdf:Description rdf:about="#re83"> <bqbiol:isDescribedBy> <rdf:Bag> <rdf:li rdf:resource="urn:miriam:pubmed:19380580" /> </rdf:Bag> </bqbiol:isDescribedBy> </rdf:Description> </rdf:RDF></annotation></qual:transition></qual:listOfTransitions></model></sbml>